The Sikkim Manipal University of Health, Medical and Technological Sciences (now known as Sikkim Manipal University) came into existence on November 15, 1992, after the signing of an agreement between the Government of Sikkim and the Manipal Pai Foundation. The aim was to impart exemplary educational opportunities and health care services in the State of Sikkim and elsewhere.
The university was established in 1995 with the passing of the Sikkim Manipal University of Health, Medical and Technological Sciences Act (Act No. 10 of 1995).
The university has two campuses: the Medical campus and the Technology campus.
SMU is recognized by the University Grants Commission under Section 2(f) of the UGC Act, 1956 vide letter No F. 9-7/96(CPP-I) dated 9 Dec 1998, and approved by the Government of India. All its courses have been approved by regulatory bodies like the Medical Council of India (MCI), Nursing Council of India, Indian Association of Physiotherapy, All India Council for Technical Education (AICTE), and the Distance Education Council.
The Sikkim Manipal University of Health, Medical, and Technological Sciences (Amendment) Act No. 13 of 2009 was passed by the Sikkim Legislative Assembly on 12 December 2009 and received the assent of the governor of Sikkim on 22 January 2010: Vide Notification No. 13/LD/P/2010, 08/04/2010 of Sikkim Government, Sikkim Manipal University of Health Medical and Technological Sciences was changed to Sikkim Manipal University.
According to the said Act, the university would be able to disseminate advanced knowledge by providing instructional and research facilities for promoting interdisciplinary studies in the university.
In 2012, the University introduced the Department of Humanities and Social Sciences. The department covers subjects like Sociology, Political Science, History, English, and Commerce.